Exercise and Aging: Boosting Cognition in Older African Americans

Published on July 22, 2022

Explore the impact of exercise on cognitive function in older African Americans! In a recent pilot trial, sedentary older individuals participated in a 12-week intervention aimed at improving cognitive outcomes. One group attended weekly educational sessions on healthy aging, while the other engaged in supervised physical activity sessions at local YMCAs, along with home-based activities. The results showed that the group participating in the healthy aging program experienced significant improvements in global cognition and select subdomain scores. In contrast, the physical activity group did not show similar improvements. Interestingly, female participants in the healthy aging program displayed greater enhancements in global cognition compared to both male participants and females in the physical activity group. Possible factors contributing to these findings include inadequate dosage or duration of physical activity and the social stimulation provided by the educational sessions. Future studies should consider combining socially engaging activities with vigorous exercise to optimize cognitive benefits for older African Americans.

IntroductionRegular physical activity lowers risk for cognitive decline and neurodegenerative disorders. Older African Americans (AAs) have been underrepresented in trials that increased physical activity to improve cognitive outcomes.Methods56 sedentary, older, cognitively healthy AAs (avg. 69.2 ± 3.4 yrs. old) were randomized in 1:1 ratio into either a 12-week successful aging group (SAG) or a 12-week physical activity group (PAG). Participants in SAG attended weekly 60-min educational sessions in which healthy aging topics were discussed. Participants in PAG attended supervised physical activity sessions twice per week at local YMCAs (90–120 min/week) and were prescribed 2–3 days per week of home-based activity. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) assessed cognitive function. ANCOVA models compared mean 12-week change in global cognition and subdomain scores between groups with secondary analyses for sex differences. Effect sizes for RBANS were calculated.ResultsThe RBANS global cognition score (SAG Est. 5.6 ± 1.8, effect size = 0.37, p = 0.003) and several subdomain scores (one-sample T tests, all p < 0.05) increased significantly within the SAG. Scores for global cognition increased more in SAG than in PAG (Change Estimate, PAG minus SAG: –4.6 ± 2.5 points, effect size = 0.31) at a trend level (p = 0.072). SAG females increased their global cognition score more than PAG females and more than males in either PAG or SAG (all p < 0.035).DiscussionA 12-week physical activity intervention (PAG) did not improve cognitive functioning among older AAs but a comparator healthy aging education program did. Inadequate physical activity dosage or duration, SAG members acting on health-related information from educational sessions, and/or social stimulation within the SAG may have contributed to these results. Future studies should combine socially engaging activities with vigorous physical activity for cognitive enhancement among cognitively healthy older African Americans.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT03474302.

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