Constipation in Parkinson’s disease (PD) is like a traffic jam on a highway before a concert – it happens before the main event. Previous studies have shown that constipation occurs even before the motor symptoms of PD kick in, and its occurrence increases as the disease progresses. However, the exact mechanisms behind this constipation are still not fully known. What we do know is that chronic constipation can slow down the absorption of vital medications used to treat PD, like levodopa and dopamine agonists. To effectively manage constipation in PD, we need to unravel the underlying molecular mechanisms and develop precise treatment strategies. This review article does just that by delving into the molecular pathology of constipation in PD and providing updates on treatment options. Whether you’re a healthcare professional or someone affected by PD, this article will help you understand the science behind constipation in PD and explore potential treatments.
Constipation, one of the most common prodromal non-motor symptoms of Parkinson’s disease (PD), usually occurs several years earlier than the onset of motor symptoms. Previous studies have shown that constipation occurrence increases as the disease progresses. However, the mechanism underlying this pathologic disorder is not clear yet. Moreover, chronic constipation causes slowness in gastric emptying and, therefore, may lead to a delay in the absorption of medications for PD, including levodopa and dopamine agonists. Accordingly, it is necessary to understand how the pathophysiological factors contribute to constipation during PD as well as pursue precise and effective treatment strategies. In this review, we encapsulate the molecular mechanism of constipation underlying PD and update the progress in the treatments of PD-associated constipation.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.