The Ferroptosis Puzzle: A New Piece to Understanding Neurodegenerative Diseases

Published on June 28, 2022

Imagine you’re trying to put together a complex puzzle and suddenly you find a brand new piece that fits perfectly! That’s the case with ferroptosis and neurodegenerative diseases. Neurodegenerative diseases like Alzheimer’s and Parkinson’s have long been puzzling scientists, with various theories about their causes and progression. But now, a new player has entered the field: ferroptosis. Think of ferroptosis as a previously unseen puzzle piece that adds another layer of understanding to these diseases. It’s a type of programmed cell death driven by iron and lipid peroxidation, and it’s proving to be linked to the occurrence and progression of neurodegenerative diseases. Scientists are now uncovering the intricate mechanisms that govern ferroptosis and its impact on the brain. By gaining a comprehensive understanding of this process, we can develop new therapeutic technologies and strategies to slow down the progression of these devastating diseases. If you’re curious to learn more about this exciting research, we encourage you to explore the underlying study!

Neurodegenerative diseases are a diverse class of diseases attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and multiple sclerosis. The pathogenesis of neurodegenerative diseases is complex and diverse, often involving mitochondrial dysfunction, neuroinflammation, and epigenetic changes. However, the pathogenesis of neurodegenerative diseases has not been fully elucidated. Recently, accumulating evidence revealed that ferroptosis, a newly discovered iron-dependent and lipid peroxidation-driven type of programmed cell death, provides another explanation for the occurrence and progression of neurodegenerative diseases. Here, we provide an overview of the process and regulation mechanisms of ferroptosis, and summarize current research progresses that support the contribution of ferroptosis to the pathogenesis of neurodegenerative diseases. A comprehensive understanding of the emerging roles of ferroptosis in neurodegenerative diseases will shed light on the development of novel therapeutic technologies and strategies for slowing down the progression of these diseases.

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