State and Trait Anxiety: Exploring the Brain’s Common Mechanisms

Published on June 23, 2022

Anxiety is like your mind going on a roller coaster, constantly preparing for potential threats in the future. It can be split into two parts: state anxiety, which comes and goes, and trait anxiety, which is more stable. But do these two dimensions of anxiety share similar brain mechanisms? That’s what this study set out to investigate! Using brain networks and connectivity, the researchers discovered that both state and trait anxiety affect specific areas of the brain. The left frontal eyes field and right insula were found to play a major role in processing anxiety. Interestingly, these brain regions showed consistent patterns over time and space. This study strengthens our understanding of how anxiety is processed in the brain and opens doors for future research into mental health. Ready to dive deeper into the fascinating world of brain network mechanisms? Check out the full article!

Anxiety is a future-oriented unpleasant and negative mental state induced by distant and potential threats. It could be subdivided into momentary state anxiety and stable trait anxiety, which play a complex and combined role in our mental and physical health. However, no studies have systematically investigated whether these two different dimensions of anxiety share a common or distinct topological mechanism of human brain network. In this study, we used macroscale human brain morphological similarity network and functional connectivity network as well as their spatial and temporal variations to explore the topological properties of state and trait anxiety. Our results showed that state and trait anxiety were both negatively correlated with the coefficient of variation of nodal efficiency in the left frontal eyes field of volume network; state and trait anxiety were both positively correlated with the median and mode of pagerank centrality distribution in the right insula for both static and dynamic functional networks. In summary, our study confirmed that state and trait anxiety shared common human brain network topological mechanisms in the insula and the frontal eyes field, which were involved in preliminary cognitive processing stage of anxiety. Our study also demonstrated that the common brain network topological mechanisms had high spatiotemporal robustness and would enhance our understanding of human brain temporal and spatial organization.

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