Epigenetics in Alzheimer’s Disease

Published on June 23, 2022

Imagine Alzheimer’s disease as a mysterious puzzle, with countless pieces that no one fully understands. Scientists have been trying to find a specific drug to target the known characteristics of Alzheimer’s, only to face failure. The drugs available on the market offer little relief and come with unwanted side effects. But wait! There might be a breakthrough! Recent studies show that epigenetic changes occur in Alzheimer’s, presenting an exciting new avenue for research. These changes in DNA methylation, histone modification, and miRNA have the potential to be the key to unlocking effective treatments for Alzheimer’s. While we don’t know yet if these changes are causing or resulting from the disease, they give us hope that new strategies can be developed. If you want to dive deeper into this groundbreaking research, check out the full article!

Alzheimer’s disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (Aβ) have ended in failure. Although there are some drugs on the market that indirectly act on AD, their efficacy is very low and the side effects are substantial, so there is an urgent need to develop a new strategy for the treatment of AD. An increasing number of studies have confirmed epigenetic changes in AD. Although it is not clear whether these epigenetic changes are the cause or result of AD, they provide a new avenue of treatment for medical researchers worldwide. This article summarizes various epigenetic changes in AD, including DNA methylation, histone modification and miRNA, and concludes that epigenetics has great potential as a new target for the treatment of AD.

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