Imagine a garden where the plants thrive when sprinkled with just the right amount of water. Similarly, exercise can work wonders for osteoarthritis (OA) by unraveling its secrets and calming its effects. With OA on the rise globally, it has become a concerning joint disease primarily affecting seniors. While current treatment options include surgery and medication, exercise therapy is gaining attention as an alternative approach. Exercise holds the promise of not just addressing OA symptoms but also delving into its root causes at a molecular level. By understanding the mechanisms behind exercise’s impact on OA – such as its effects on the degradation of ECM, apoptosis, inflammatory response, autophagy, and changes in ncRNA – we can tailor exercise prescriptions to prevent and combat OA effectively. Researchers have found that different exercise modalities, intensities, durations, and frequencies yield varying outcomes for OA patients. This enlightening literature review goes deep into these aspects and proposes suitable exercise prescriptions for individuals plagued by OA.
Osteoarthritis (OA) has a very high incidence worldwide and has become a very common joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug therapy, and exercise therapy. In recent years, the treatment of certain diseases by exercise has received increasing research and attention. Proper exercise can improve the physiological function of various organs of the body. At present, the treatment of OA is usually symptomatic. Limited methods are available for the treatment of OA according to its pathogenesis, and effective intervention has not been developed to slow down the progress of OA from the molecular level. Only by clarifying the mechanism of exercise treatment of OA and the influence of different exercise intensities on OA patients can we choose the appropriate exercise prescription to prevent and treat OA. This review mainly expounds the mechanism that exercise alleviates the pathological changes of OA by affecting the degradation of the ECM, apoptosis, inflammatory response, autophagy, and changes of ncRNA, and summarizes the effects of different exercise types on OA patients. Finally, it is found that different exercise types, exercise intensity, exercise time and exercise frequency have different effects on OA patients. At the same time, suitable exercise prescriptions are recommended for OA patients.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.