Imagine you’re investigating a crime scene, trying to connect the evidence to the suspect. Well, scientists are doing something similar with Alzheimer’s disease (LOAD). They want to find out which biomarkers in our bodies can predict the progression of Alzheimer’s. By using a method called polygenic risk score (AD-PRS), they have discovered that certain genetic characteristics can indicate the likelihood of developing Alzheimer’s. But they didn’t stop there! They went a step further and looked at various biomarkers like brain scans, cerebrospinal fluid, blood samples, cardiovascular risk factors, cognition, and mental health. This comprehensive review has given us valuable insights into how these biomarkers may be linked to Alzheimer’s. It’s like unlocking clues to a mystery that could help us develop better treatments and interventions for this devastating disease. To dive deeper into the research behind these connections, check out the full article!
Late-onset Alzheimer’s disease (LOAD) is a common irreversible neurodegenerative disease with heterogeneous genetic characteristics. Identifying the biological biomarkers with the potential to predict the conversion from normal controls to LOAD is clinically important for early interventions of LOAD and clinical treatment. The polygenic risk score for LOAD (AD-PRS) has been reported the potential possibility for reliably identifying individuals with risk of developing LOAD recently. To investigate the external phenotype changes resulting from LOAD and the underlying etiology, we summarize the comprehensive associations of AD-PRS with multiple biomarkers, including neuroimaging, cerebrospinal fluid and plasma biomarkers, cardiovascular risk factors, cognitive behavior, and mental health. This systematic review helps improve the understanding of the biomarkers with potential predictive value for LOAD and further optimizing the prediction and accurate treatment of LOAD.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.