The Complex Relationship Between Aging and Brain Injury

Published on April 25, 2022

Intracerebral hemorrhage (ICH) is like a storm in the brain, causing devastating damage. Unfortunately, our understanding of this disorder is still limited. Most research has focused on young animals, ignoring the impact of aging. This means we don’t fully know how the aging brain responds to ICH. This review aims to shed light on the effects of age on ICH-induced brain injury and recovery, highlighting important gaps in our knowledge that need further investigation. Understanding the intricate relationship between aging and brain injury could help improve treatments for ICH patients and increase their chances of regaining functional independence. Let’s dive into the research to uncover the secrets of the aging brain and its response to the storm of ICH!

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high rates of mortality and morbidity. ICH patients often suffer devastating and debilitating neurological impairments, from which the majority of victims are unable to fully recover to functional independence. Unfortunately, there is no established medical therapy for ICH, which is partly attributed to the lack of understanding of the complex pathology of the disorder. Despite advanced age being a major risk factor of ICH, most preclinical studies on ICH employed young animal subjects. Due to this discrepancy, the molecular level changes in the aging brain after ICH are largely unknown, limiting the translation of preclinical studies into potential human treatments. The purpose of this review is to highlight the effects of advanced age on ICH- induced brain injury and recovery and to draw attention to current knowledge gaps, which warrant further investigation.

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