Just like using antibiotics too often can lead to antibiotic resistance, it seems that long-term or repeated use of antibiotics in childhood might have a negative impact on cognitive function later in life. A recent cohort study analyzed data from the UK Biobank Database and found that individuals who were exposed to antibiotics in their younger years had an 18% increased risk of developing cognitive impairment in middle and old age compared to those who didn’t have as much antibiotic exposure. This effect was consistent across various factors like sex, age, ethnic groups, and lifestyle variables, but interestingly, the level of education seemed to modify the relationship between antibiotic use and cognitive impairment. While the exact mechanism behind this association is still unclear, it’s possible that alterations in the gut microbiome caused by antibiotics could play a role. Regardless, these findings underscore the importance of judicious antibiotic use, especially in children and adolescents. If you’re interested in learning more about this study and its implications, be sure to check out the full article!
ObjectivesWe evaluated the effects of long-term/recurrent use of antibiotics in childhood on developing cognitive impairment in middle and old age from UK Biobank Database.MethodsUK Biobank recruited participants aged 37–73 years. Cognitive impairment was ascertained by fluid intelligence questionnaire. Primary outcome was the occurrence of cognitive impairment in middle and old age. Multivariate logistic regression models were used to explore the relationship between long-term/recurrent use of antibiotics and cognitive impairment.ResultsOver 3.8–10.8 years’ follow-up, 4,781 of the 35,921 participants developed cognitive impairment. The odds of cognitive impairment in middle and old age among long-term/recurrent use of antibiotics in childhood were increased by 18% compared with their counterparts (adjusted odd ratio 1.18, 95% confidence interval 1.08–1.29, p < 0.01). The effect of long-term/recurrent use of antibiotics in childhood on cognitive impairment was homogeneous across different categories of various subgroup variables such as sex, age, APOE4, ethnic groups, income before tax, smoking status, alcohol status, BMI, hypertension and diabetes but the effect of long-term/recurrent use of antibiotics in childhood was modified by the educational qualification (p-value for interaction <0.05).ConclusionLong-term/recurrent use of antibiotics in childhood may increase the risk of cognitive impairment in middle and old age.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.