An ‘oracle’ for predicting the evolution of gene regulation

Published on March 9, 2022

Computational biologists have created a neural network model capable of predicting how changes to non-coding DNA sequences in yeast affect gene expression. They also devised a unique way of representing this data in two dimensions, making it easy to understand the past and future evolution of non-coding sequences in organisms beyond yeast — and even design custom gene expression patterns for gene therapies and industrial applications. Despite the sheer number of genes that each human cell contains, these so-called ‘coding’ DNA sequences comprise just 1% of our entire genome. The remaining 99% is made up of ‘non-coding’ DNA — which, unlike coding DNA, does not carry the instructions to build proteins.

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