Month: November 2021

Survey: Many Still Nervous About Holiday Gatherings

For Emily Litvin, this Thanksgiving is going to look different from the last one and she couldn’t be happier about it. “I’m so excited to have some sort of normalcy, especially for my daughter and her cousins. It’s nice for them to all get together and experience the… Read Full Article (External Site) Dr. David […]

Published on November 15, 2021

Proportional Changes in Cognitive Subdomains During Normal Brain Aging

Background: Neuroscience lacks a reliable method of screening the early stages of dementia.Objective: To improve the diagnostics of age-related cognitive functions by developing insight into the proportionality of age-related changes in cognitive subdomains.Materials and Methods: We composed a battery of psychophysiological tests and collected an open-access psychophysiological outcomes of brain atrophy (POBA) dataset by testing […]

Published on November 15, 2021

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or decreased NAAG-mGluR3 are associated with impaired prefrontal cortical (PFC) activation and cognitive impairment. As aging […]

Published on November 15, 2021