Month: October 2021

Cerebral Vasoreactivity Changes Over Time in Patients With Different Clinical Manifestations of Cerebral Small Vessel Disease

Objectives: Endothelial dysfunction (ED) has been linked to the pathogenesis of cerebral small vessel disease (SVD). We aimed to assess ED and cerebrovascular reactivity (CVR) in the patients with a diverse manifestation of SVD, with similar and extensive white matter lesions (WMLs, modified Fazekas scale grade ≥2), compared with a control group (CG) without the […]

Published on October 20, 2021

The Correlation Between Olfactory Test and Hippocampal Volume in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Meta-Analysis

Background: Previous studies have reported that olfactory identification deficits may be the earliest clinical features of Alzheimer’s disease (AD). However, the association between odor identification and hippocampal atrophy remains unclear.Objective: This meta-analysis quantified the correlation between odor identification test scores and hippocampal volume in AD.Method: A search of the PUBMED, EMBASE, and WEB OF SCIENCE […]

Published on October 20, 2021

Methamphetamine and Modulation Functionality of the Prelimbic Cortex for Developing a Possible Treatment of Alzheimer’s Disease in an Animal Model

Alzheimer’s disease (AD) is a progressive neurodegenerative condition that causes cognitive impairment and other neuropsychiatric symptoms. Previously, little research has thus far investigated whether methamphetamine (MAMPH) can enhance cognitive function or ameliorate AD symptoms. This study examined whether a low dose of MAMPH can induce conditioned taste aversion (CTA) learning, or can increase plasma corticosterone […]

Published on October 20, 2021