Month: September 2021

Intense workouts before bedtime won’t guarantee a good night’s rest, new research shows

A new meta-analysis assessed data from 15 published studies to see how a single session of intense exercise affects young and middle-aged healthy adults in the hours prior to bedtime. And while no two bodies are the same, the researchers did find that the combination of factors would interact to enhance or modulate the effects […]

Published on September 28, 2021

Generalised Analog LSTMs Recurrent Modules for Neural Computing

The human brain can be considered as a complex dynamic and recurrent neural network. There are several models for neural networks of the human brain, that cover sensory to cortical information processing. Large majority models include feedback mechanisms that are hard to formalise to realistic applications. Recurrent neural networks and Long short-term memory (LSTM) inspire […]

Published on September 28, 2021

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

Objective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers (Parkin-PD) and healthy controls.Background: Mitochondria, including mtDNA, are established key players in Parkinson’s disease (PD) pathogenesis. Mutations in Parkin, essential for degradation of damaged mitochondria, cause early-onset PD. However, […]

Published on September 28, 2021