Results: No significant difference was found between MCI-A and MCI-NA (P >0.05) in cognitive ability. Regarding intrinsic brain activity, MCI-A had increased sALFF and dALFF variance in the anterior cingulate cortex (ACC) relative to MCI-NA, as well as decreased sALFF and dALFF variance in the precuneus relative to MCI-NA and controls. Moreover, MCI-A had decreased sALFF in the inferior temporal gyrus (ITG) and paracentral lobule (PCL) compared to MCI-NA. Among all subjects, correlation analyses showed that the sALFF and dALFF variance in precuneus was related to the Ecog discrepancy score (r=0.215 and 0.223, respectively) and delayed story recall (r=0.225 and 0.267, respectively).
Conclusion: Alterations of intrinsic brain activation in ACC and precuneus may account for the anosognosia symptom in MCI patients.