Month: August 2021

Just Starting Exercise in Your 60s? It Still Helps Your Heart

If you’re a 60-something with heart disease, it’s not too late to give your ticker the benefits of a regular workout. Swiss researchers found that survival rates among heart patients who became active later in life were nearly the same as those who’d been exercising for… Read Full Article (External Site) Dr. David LowemannDr. David […]

Published on August 25, 2021

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice

General anesthetics can induce cognitive impairments and increase the risk of Alzheimer’s disease (AD). However, the underlying mechanisms are still unknown. Our previous studies shown that long-term isoflurane exposure induced peripheral and central insulin resistance (IR) in adult mice and aggravated IR in type 2 diabetes mellitus (T2DM) mice. Clinical and preclinical studies revealed an […]

Published on August 25, 2021

Cognitive Trajectories and Dementia Risk: A Comparison of Two Cognitive Reserve Measures

Background and ObjectivesCognitive reserve (CR) is meant to account for the mismatch between brain damage and cognitive decline or dementia. Generally, CR has been operationalized using proxy variables indicating exposure to enriching activities (activity-based CR). An alternative approach defines CR as residual variance in cognition, not explained by the brain status (residual-based CR). The aim […]

Published on August 25, 2021