Month: June 2021

ADVIAN: Alzheimer’s Disease VGG-Inspired Attention Network Based on Convolutional Block Attention Module and Multiple Way Data Augmentation

Aim: Alzheimer’s disease is a neurodegenerative disease that causes 60–70% of all cases of dementia. This study is to provide a novel method that can identify AD more accurately.Methods: We first propose a VGG-inspired network (VIN) as the backbone network and investigate the use of attention mechanisms. We proposed an Alzheimer’s Disease VGG-Inspired Attention Network […]

Published on June 18, 2021

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

Poly (ADP-ribose) (PAR) is a negatively charged polymer that is biosynthesized by Poly (ADP-ribose) Polymerase-1 (PARP-1) and regulates various cellular processes. Alpha-synuclein (αSyn) is an intrinsically disordered protein (IDP) that has been directly implicated with driving the onset and progression of Parkinson’s disease (PD). The mechanisms by which α-synuclein (αSyn) elicits its neurotoxic effects remain […]

Published on June 18, 2021

APP, PSEN1, and PSEN2 Variants in Alzheimer’s Disease: Systematic Re-evaluation According to ACMG Guidelines

The strategies of classifying APP, PSEN1, and PSEN2 variants varied substantially in the previous studies. We aimed to re-evaluate these variants systematically according to the American college of medical genetics and genomics and the association for molecular pathology (ACMG-AMP) guidelines. In our study, APP, PSEN1, and PSEN2 variants were collected by searching Alzforum and PubMed […]

Published on June 18, 2021