Month: April 2021

CRBA: A Competitive Rate-Based Algorithm Based on Competitive Spiking Neural Networks

In this paper we present a Competitive Rate-Based Algorithm (CRBA) that approximates operation of a Competitive Spiking Neural Network (CSNN). CRBA is based on modeling of the competition between neurons during a sample presentation, which can be reduced to ranking of the neurons based on a dot product operation and the use of a discrete […]

Published on April 22, 2021

Emergence of Neuronal Synchronisation in Coupled Areas

One of the most fundamental questions in the field of neuroscience is the emergence of synchronous behaviour in the brain, such as phase, anti-phase, and shift-phase synchronisation. In this work, we investigate how the connectivity between brain areas can influence the phase angle and the neuronal synchronisation. To do this, we consider brain areas connected […]

Published on April 22, 2021

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model

Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilysin is a potent drug to degrade plaques. The major challenge is to deliver bioactive neprilysin into the brain via the blood-brain […]

Published on April 22, 2021