Month: January 2021

Protective Effect of the α7 Nicotinic Receptor Agonist PNU-282987 on Dopaminergic Neurons Against 6-Hydroxydopamine, Regulating Anti-neuroinflammatory and the Immune Balance Pathways in Rat

Neuroinflammation and inner immune dysfunction are increasingly accepted as important components of the etiopathogenesis of Parkinson’s disease (PD). According to emerging evidence, a7 nicotinic acetylcholine receptor (α7nAChR), a ligand-gated ion channel, plays an important role in inflammatory reactions and is also expressed on the surface of T cells. In particular, regulatory T cells (Tregs) are […]

Published on January 25, 2021

Motor Progression in Early-Stage Parkinson’s Disease: A Clinical Prediction Model and the Role of Cerebrospinal Fluid Biomarkers

Background: The substantial heterogeneity of clinical symptoms and lack of reliable progression markers in Parkinson’s disease (PD) present a major challenge in predicting accurate progression and prognoses. Increasing evidence indicates that each component of the neurovascular unit (NVU) and blood-brain barrier (BBB) disruption may take part in many neurodegenerative diseases. Since some portions of CSF […]

Published on January 25, 2021

Meal Plans vs. Flexible Dieting for Fat Loss

Which of these tried-and-true diet approaches is right for you? Consider the pros and cons. Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a […]

Published on January 25, 2021