Month: November 2020

Sleep loss hijacks brain’s activity during learning

Sleep is crucial for consolidating our memories, and sleep deprivation has long been known to interfere with learning and memory. Now a new study shows that getting only half a night’s sleep – as many medical workers and military personnel often do – hijacks the brain’s ability to unlearn fear-related memories. That might put people […]

Published on November 11, 2020

Hierarchical Sequencing and Feedforward and Feedback Control Mechanisms in Speech Production: A Preliminary Approach for Modeling Normal and Disordered Speech

Our understanding of the neurofunctional mechanisms of speech production and their pathologies is still incomplete. In this paper, a comprehensive model of speech production based on the Neural Engineering Framework (NEF) is presented. This model is able to activate sensorimotor plans based on cognitive-functional processes (i.e., generation of the intention of an utterance, selection of […]

Published on November 11, 2020

Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer’s Disease Leads to Neuroglial and Endothelial Cell Degeneration

Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). Recently, neurovascular dysfunction and altered systemic immunological components have been linked to AD neurodegeneration. Therefore, we characterized systemic-EVs from postmortem SAD […]

Published on November 11, 2020