Excitation-inhibition (E-I) balanced neural networks are a classic model for modeling neural activities and functions in the cortex. The present study investigates the potential application of E-I balanced neural networks for fast signal detection in brain-inspired computation. We first theoretically analyze the response property of an E-I balanced network, and find that the asynchronous firing […]

Mild cognitive impairment (MCI) is a clinical state with a high risk of conversion to Alzheimer’s Disease (AD). Since there is no effective treatment for AD, it is extremely important to diagnose MCI as early as possible, as this makes it possible to delay its progression toward AD. However, it’s challenging to identify early MCI […]

Reactive oxygen species and reactive nitrogen species (RONS) are by-products of aerobic metabolism. RONS trigger a signaling cascade that can be transduced through oxidation-reduction (redox)-based post-translational modifications (redox PTMs) of protein thiols. This redox signaling is essential for normal cellular physiology and coordinately regulates the function of redox-sensitive proteins. It plays a particularly important role […]