Alzheimer’s disease (AD) is pathologically defined by extracellular accumulation of amyloid-β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of hyperphosphorylated Tau proteins accumulating inside neurons known as neurofibrillary tangles (NFTs) and neuronal loss. The association between the two hallmarks and cognitive decline has been known since the beginning of the […]
Published on August 27, 2020
Protein homeostasis, or proteostasis, is a combination of cellular processes that govern protein quality control, namely, protein translation, folding, processing, and degradation. Disruptions in these processes can lead to protein misfolding and aggregation. Proteostatic disruption can lead to cellular changes such as endoplasmic reticulum or oxidative stress; organelle dysfunction; and, if continued, to cell death. […]
Published on August 27, 2020
Being able to take control of your fitness, nutrition, and overall health doesn’t happen by magic. If you’re looking to build the type of self-discipline that will help you earn better workouts and better results, it all starts with these three simple steps. Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, M.Sc, Ph.D., […]
Published on August 27, 2020