In this paper, we focus on the emergence of diverse neuronal oscillations arising in a mixed population of neurons with different excitability properties. These properties produce mixed mode oscillations (MMOs) characterized by the combination of large amplitudes and alternate subthreshold or small amplitude oscillations. Considering the biophysically plausible, Izhikevich neuron model, we demonstrate that various MMOs, including MMBOs (mixed mode bursting oscillations) and synchronized tonic spiking appear in a randomly connected network of neurons, where a fraction of them is in a quiescent (silent) state and the rest in self-oscillatory (firing) states. We show that MMOs and other patterns of neural activity depend on the number of oscillatory neighbors of quiescent nodes and on electrical coupling strengths. Our results are verified by constructing a reduced-order network model and supported by systematic bifurcation diagrams as well as for a small-world network. Our results suggest that, for weak couplings, MMOs appear due to the de-synchronization of a large number of quiescent neurons in the networks. The quiescent neurons together with the firing neurons produce high frequency oscillations and bursting activity. The overarching goal is to uncover a favorable network architecture and suitable parameter spaces where Izhikevich model neurons generate diverse responses ranging from MMOs to tonic spiking.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
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