Brain structural network changes provide key information about the aging process of the brain. Unfortunately, there has yet to be a detailed characterization of these structural networks across different age groups. Efforts to classify these networks have also been hampered by their reliance on technically limited traditional methods, which are unable to track multiple fiber orientations within a voxel and consequently are prone to false detection and artifacts. In this study, a newly developed Ensemble Average Propagator (EAP) based probabilistic tractography method was applied to construct a structural network, with the strength of the link between any two brain functional regions estimated according to the alignment of the EAP along connecting pathways. Age-related changes in the topological organization of human brain structural networks were thereby characterized across a broad age range (ages 8–75 years). The data from 48 healthy participants were divided into four age groups (Group 1 aged 8–15 years; Group 2 aged 25–35 years; Group 3 aged 45–55 years; and, Group 4 aged 65–75 years; N = 12 per group). We found that the brain structural network continues to strengthen during later adolescence and adulthood, through the first 20–30 years of life. Older adults, aged 65–75, had a significantly less optimized topological organization in their structural network, with decreased global efficiency and increased path lengths versus subjects in other groups. This study suggests that probabilistic tractography based on EAP provides a reliable method to construct macroscale structural connectivity networks to capture the age-associated changes of brain structures.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.