Month: February 2020

Prefrontal Consolidation and Compensation as a Function of Wearing Denture in Partially Edentulous Elderly Patients

BackgroundThe cognitive effects of wearing a denture are not well understood. This study was conducted to clarify the effects of denture use on prefrontal and chewing muscle activities, occlusal state, and subjective chewing ability in partially edentulous elderly individuals.MethodsA total of 16 partially edentulous patients were enrolled. Chewing-related prefrontal cortex and jaw muscle activities were […]

Published on February 3, 2020

The Decline in Intrinsic Connectivity Between the Salience Network and Locus Coeruleus in Older Adults: Implications for Distractibility

We examined functional connectivity between the locus coeruleus (LC) and the salience network in healthy young and older adults to investigate why people become more prone to distraction with age. Recent findings suggest that the LC plays an important role in focusing processing on salient or goal-relevant information from multiple incoming sensory inputs (Mather et […]

Published on February 3, 2020

Strategies for the Treatment of Parkinson’s Disease: Beyond Dopamine

Parkinson’s disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This […]

Published on February 3, 2020