Two strikingly distinct types of activity have been observed in various brain structures during delay periods of delayed response tasks: Persistent activity (PA), in which a sub-population of neurons maintains an elevated firing rate throughout an entire delay period; and Sequential activity (SA), in which sub-populations of neurons are activated sequentially in time. It has been hypothesized that both types of dynamics can be “learned” by the relevant networks from the statistics of their inputs, thanks to mechanisms of synaptic plasticity. However, the necessary conditions for a synaptic plasticity rule and input statistics to learn these two types of dynamics in a stable fashion are still unclear. In particular, it is unclear whether a single learning rule is able to learn both types of activity patterns, depending on the statistics of the inputs driving the network. Here, we first characterize the complete bifurcation diagram of a firing rate model of multiple excitatory populations with an inhibitory mechanism, as a function of the parameters characterizing its connectivity. We then investigate how an unsupervised temporally asymmetric Hebbian plasticity rule shapes the dynamics of the network. Consistent with previous studies, we find that for stable learning of PA and SA, an additional stabilization mechanism is necessary. We show that a generalized version of the standard multiplicative homeostatic plasticity (Renart et al., 2003; Toyoizumi et al., 2014) stabilizes learning by effectively masking excitatory connections during stimulation and unmasking those connections during retrieval. Using the bifurcation diagram derived for fixed connectivity, we study analytically the temporal evolution and the steady state of the learned recurrent architecture as a function of parameters characterizing the external inputs. Slow changing stimuli lead to PA, while fast changing stimuli lead to SA. Our network model shows how a network with plastic synapses can stably and flexibly learn PA and SA in an unsupervised manner.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
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