Month: January 2020

White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline

Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer’s disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and their correlation with cognitive function in these AD-spectrum patients.Methods: Diffusion tensor images […]

Published on January 29, 2020

Differences Between Human and Murine Tau at the N-terminal End

Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R […]

Published on January 29, 2020

Finessing the Bored Monkey Problem

By recording from microelectrodes in monkey prefrontal cortex (PFC), researchers have decoded the contents of conscious perception in cognitive areas (lateral prefrontal cortex) in conditions in which perceptions are not determined by the stimulus, binocular rivalry, and flash suppression [1–4]. As I noted in my recent Trends in Cognitive Sciences article [5], such results cannot […]

Published on January 29, 2020