Month: December 2019

Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain

The formation of senile plaques through amyloid-β peptide (Aβ) aggregation is a hallmark of Alzheimer’s disease (AD). Irrespective of its actual role in the synaptic alterations and cognitive impairment associated with AD, different therapeutic approaches have been proposed to reduce plaque formation. In rodents, daily intake of omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFAs) is […]

Published on December 19, 2019

Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model

Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition along with glial distribution in normal C57Bl/6J mice aged 2-, 6-, […]

Published on December 19, 2019

Ask the Ageless Lifter: Can I Skip Deadlifts?

Does the prospect of picking up a barbell off the ground at your age (no matter what that age is) feel daunting? Luckily for you, there are plenty of other strength-building options at your disposal! Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the […]

Published on December 19, 2019