Month: September 2019

Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD

Objective: To examine the prospective association between blood biomarkers of immune functioning (i.e., innate immune activation, adaptive immunity, and inflammation) and subsequent cognitive decline and clinical progression to mild cognitive impairment (MCI) in cognitively normal individuals. Methods: The BIOCARD study is an observational cohort study of N=191 initially cognitively healthy participants (mean age 65.2 years). […]

Published on September 7, 2019

The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia

Nowadays, Alzheimer’s disease (AD) is a severe sociological and clinical problem. Since it was first described, there has been a constant increase in its incidence and, for now, there are no effective treatments since current approved medications have only shown short-term symptomatic benefits. Therefore, it is imperative to increase efforts in the search for molecules […]

Published on September 7, 2019

Accelerated Ovarian Failure as a Unique Model to Study Peri-Menopause Influence on Alzheimer’s Disease

Despite decades of extensive research efforts, efficacious therapies for Alzheimer’s disease (AD) are lacking. The multi-factorial nature of AD neuropathology and symptomatology has taught us that a single therapeutic approach will most likely not fit all. Women constitute ~70% of the affected AD population, and pathology and rate of symptoms progression are 2-3 times higher […]

Published on September 7, 2019