Month: September 2019

Recurrence Resonance” in Three-Neuron Motifs

Stochastic Resonance (SR) and Coherence Resonance (CR) are non-linear phenomena, in which an optimal amount of noise maximizes an objective function, such as the sensitivity for weak signals in SR, or the coherence of stochastic oscillations in CR. Here, we demonstrate a related phenomenon, which we call “Recurrence Resonance” (RR): noise can also improve the […]

Published on September 11, 2019

PET Imaging of Astrogliosis and Tau Facilitates Diagnosis of Parkinsonian Syndromes

Neurodegenerative parkinsonian syndromes comprise a number of disorders that are characterized by similar clinical features but are separated on the basis of different pathologies, i.e., aggregates of α-synuclein or tau protein. Due to the overlap of signs and symptoms a precise differentiation is often difficult, especially early in the disease course. Enormous efforts have been […]

Published on September 11, 2019

Longitudinal Assessment of Amyloid-β Deposition by [18F]-Flutemetamol PET Imaging Compared With [11C]-PIB Across the Spectrum of Alzheimer’s Disease

This study evaluates the longitudinal changes in the amyloid-β (Aβ) deposition with [18F]-flutemetamol (FMM) PET imaging across the spectrum of Alzheimer’s disease (AD), compared with [11C]-Pittsburgh Compound-B (PIB) PET. Eleven AD, 17 mild cognitive impairment (MCI) and 13 cognitively normal (CN) subjects underwent neuropsychological assessment and amyloid PET imaging using [18F]-FMM and [11C]-PIB during a […]

Published on September 11, 2019