Hallmarks of Alzheimer’s disease (AD) pathology include acetylcholine deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid beta (Aβ) to promote aggregation of insoluble amyloid beta plaques in brains of patients. Current therapeutic options available for AD patients, such as AChE inhibitors, provide only symptomatic relief. In this study, we […]
Published on August 27, 2019
Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipains protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of it’s presence in a PD population. We confirm […]
Published on August 27, 2019
The accumulation of human islet amyloid polypeptide （hIAPP） in pancreatic islets under induction by a high-fat diet plays a critical role in the development of type-2 diabetes mellitus (T2DM). T2DM is a risk factor of late-onset Alzheimer’s disease (AD). Nevertheless, whether hIAPP in combination with hyperlipidemia may lead to AD-like pathological changes in the brain […]
Published on August 27, 2019
