Sculpting Remote Memory: Enduring Hippocampal Traces and vmPFC Reconstructive Processes

Published on July 1, 2019

Barry and Maguire’s (hereafter B&M) recent take in TiCS on the role of the hippocampus in remote memory retrieval, that it has a (scene) constructive role, rather than being part of the long-lasting representation of rich and detailed episodic memories, is both thoughtful and provocative [1]. They make two main claims: (i) the underlying cellular physiology of the hippocampus, including the existence of lifelong neurogenesis in the dentate gyrus, creates an unstable basis for remote or permanent memory; and (ii) existing data from behavioral and neuroimaging studies, in animals and humans, can be explained without assuming that the hippocampus remains a critical part of the representation of remote memories.

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