During the last decade several papers reported a relationship between advanced age and changes in the integrity of the blood-brain barrier. These alterations manifested not only in the morphology and structure of the cerebral microvessels but also in the expression and function of the transporter proteins in the apical and basolateral surface of the capillary endothelial cells. Age-associated downregulation of the efflux pumps (ABC transporters) resulted in increased permeability and greater brain exposure to different xenobiotics enhancing the risk of drug-induced toxicity. In age-related neurodegenerative pathologies like Alzheimer’s disease the amyloid beta clearance decreased due to P-glycoprotein dysfunction leading to higher brain exposure. In the contrary, in stroke an enhanced P-glycoprotein function was reported in the cerebral capillaries making even more difficult to perform effective neuroprotective therapy in the infarcted brain area. This article is focusing on the role of efflux transporters at the blood-brain barrier in age-related brain pathologies and also in healthy aging.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.