Despite subjective cognitive decline (SCD), a preclinical stage of Alzheimer’s disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals with SCD and normal controls (NCs). Forty individuals with SCD and fifty-three well-matched NCs underwent a resting-state functional magnetic resonance imaging scan. We assessed individual dynamic functional connectivity using sliding window correlations. In each time window, brain regions with a high degree centrality were defined as hubs. Across the entire time window, the proportion of time that the hub appeared was characterized as centrality frequency. The centrality frequency correlated with cognitive performance differently in individuals with SCD and NCs. Our results revealed that in individuals with SCD, compared with NCs, correlations between centrality frequency of the anterior cortical regions and cognitive performance decreased (79.2% for NCs and 43.5% for individuals with SCD). In contrast, correlations between centrality frequency of the posterior cortical regions and cognitive performance increased in SCD individuals compared with NCs (20.8% for NCs and 56.5% for individuals with SCD). Moreover, the changes mainly focused on the anterior (93.3% for NCs and45.5% for individuals with SCD) and posterior (6.7% for NCs and 54.5% for individuals with SCD) regions associated with the default mode network (DMN). In addition, we used absolute thresholds (correlation efficient r = 0.2, 0.25) and proportional thresholds (sparsity = 0.2, 0.25) to verify the results. Dynamic results are relative stable at absolute thresholds while static results are relative stable at proportional thresholds. Converging findings provide a new framework for the detection of the changes occurring in individuals with SCD via centrality frequency of the DMN.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.