The Heterogeneity Problem: Approaches to Identify Psychiatric Subtypes

Published on May 30, 2019

The imprecise nature of psychiatric nosology restricts progress towards characterizing and treating mental health disorders. One issue is the ‘heterogeneity problem’: different causal mechanisms may relate to the same disorder, and multiple outcomes of interest can occur within one individual. Our review tackles this heterogeneity problem, providing considerations, concepts, and approaches for investigators examining human cognition and mental health. We highlight the difficulty of pure dimensional approaches due to ‘the curse of dimensionality’.

Read Full Article (External Site)