Many brain regions communicate information through synchronized network activity. Electrical coupling among the dendrites of interneurons in the cortex has been implicated in forming and sustaining such activity in the cortex. Evidence for the existence of electrical coupling among cortical pyramidal cells, however, has been largely absent. A recent experimental study measured properties of electrical connections between pyramidal cells in the cortex, deemed “electrotonic couplings.” These junctions were seen to occur pair-wise, sparsely, and often coexist with electrically-coupled interneurons. Here, we construct a network model to investigate possible roles for these rare, electrotonically-coupled pyramidal-cell pairs. Through simulations, we show that electrical coupling among pyramidal-cell pairs significantly enhances coincidence-detection capabilities and increases network spike-timing precision. Further, a network containing multiple pairs possesses a rich coding structure, exhibiting large variability in its firing pattern.
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Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
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