Testing Models of Human Declarative Memory at the Single-Neuron Level

Published on April 26, 2019

Deciphering the mechanisms of declarative memory is a major goal of neuroscience. While much theoretical progress has been made, it has proven difficult to experimentally verify key predictions of some foundational models of memory. Recently, single-neuron recordings in human patients have started to provide direct experimental verification of some theories, including mnemonic evidence accumulation, balance-of-evidence for confidence judgments, sparse coding, contextual reinstatement, and the ventral tegmental area (VTA)–hippocampus loop model.

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