Recent studies (Hu and Iannetti Proc. Natl. Acad. Sci. U. S. A. 2019;116:1782–1791 and Tan et al. Nat. Commun. 2019;10:983) in animals and humans provide converging evidence that gamma oscillations in the primary somatosensory cortex are closely and causally related to pain behavior and pain perception. These findings could help to identify brain-based markers of pain, as well as urgently needed novel targets for pain therapeutics.
