Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy have a three-fold higher risk of mortality and/or cardiovascular events. Scientists have now addressed characteristics determining metabolic health in lean, overweight and obese people, showed that a reduced accumulation of fat in the lower body puts lean people at risk and highlighted implications of their findings for personalized prevention and treatment of cardiometabolic diseases.
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